PLOS Genet
On the basis of such standard assays, different isoforms are hereinafter referred to as enzymatically active or inactive glutaredoxins for the sake of simplicity (without excluding the possibility that inactive isoforms might actually catalyse other reactions with specialized substrates in vivo )
This mild acidic nature has been successfully employed in cancer theranostics like stimuli-responsive drug release, accurate diagnosis of tumor state, and micro-metastasis tracking [26, 35, 36]
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Direct inactivation is done by binding to the active site of enzymes containing copper ion, while indirect inactivation eliminates free radicals and peroxides in antioxidative manners